UROP Proceedings 2020-21

School of Engineering Department of Mechanical and Aerospace Engineering 175 Development of low-cost rapid pathogen detection microsystem in COVID-19 Pandemic: Micro PCR module- Bioengineering Approach Supervisor: LEE Yi-Kuen / MAE Student: LEUNG Kit Hin / AERO Course: UROP1000, Summer This report discusses the finding of the heating experiment of a MCH heating board with the use of Arduino kit and code. After conducting the heating experiment, it was found that temperature of the heating board increased in a faster manner when the input voltage was higher and shorter time was needed for it to attain the required temperature. Apart from the above finding, there was another observation made in the experiment. In order to heat up the board to a higher temperature, a larger input voltage is required to complete this task because of the different temperature limits for various voltage values. It might take a long time for the heater to attain a higher temperature if the voltage is kept constant. Development of Low-cost Smartphone-based Microscope for Global Health Supervisor: LEE Yi-Kuen / MAE Student: LEUNG Chi San Ivor / PHYS Course: UROP1100, Summer The first prototype of a low-cost fluorescence microscope is constructed. The prototype comprises a creditcard-size Raspberry Pi computer integrated with a high-quality camera module, commercial microscope objective lenses and other materials such as 3Dprinted components. Its performance is evaluated and compared with a commercial microscope, Olympus IX 70, in the bright-field mode in the following aspects: resolving power, image quality, and signal-to-noise ratio. Assessment results show that the prototype performs comparably to the commercial microscope. In particular, it demonstrates a higher signal-to-noise ratio than the commercial microscope. Besides the performance analysis, we also discuss some possible improvements to turn the prototype into a more suitable equipment in low-cost point-of-care medical diagnostic systems.