UROP Proceedings 2020-21

School of Science Division of Life Science 21 Receptor Based Drug Development from Chinese Herbal Medicine Supervisor: LI Ning / LIFS Co- supervisor: XUE Hong / LIFS Student: LEE Jiho / BIOT Course: UROP2100, Summer Plant-based compounds are recently acknowledged as a potential therapeutic compounds. Wogonin, a member of the flavone family, is one of the academically recognized compounds which shows high anxiolytic activity substituting benzodiazepine. However, due to its structural similarity with other flavonoids — Baicalein and Oroxylin-A, the chemical isolation and purification of wogonin has faced difficulty. In this report, results from analytical HPLC with different solvents will be shared with an amendment on Dispersed Mobilephase Countercurrent Chromatography (DMCC). Receptor Based Drug Development from Chinese Herbal Medicine Supervisor: LI Ning / LIFS Co- supervisor: XUE Hong / LIFS Student: WONG Hiu Man / BCB Course: UROP2100, Summer Aging involves progressive degeneration of bodily function and often associated with anxiety psychologically. With the rapid worldwide aging population, numerous anti-aging potential candidates have been proposed to ameliorate the age-related ailments and enhance youthful characteristics. However, most of the potential candidates are poorly investigated and have not yet reached preclinical study. Additionally, there is limited drug candidates with synergistic anti-aging and anti-anxiety effect. This report will compare the behavioural test results of mice treated with the saline and drug, which is developed by this laboratory. The antianxiolytic effect can be demonstrated by the behavioural tests while anti-aging effect and safety of the drug require further research investigation. Anticancer Drug Resistant Mechanisms Supervisor: LIANG Chun / LIFS Student: CHEUNG Yan Tung / SSCI Course: UROP1100, Fall Cancer is one of the top killers in human population. Therefore, there is a urgent need for the research of cancer therapeutics and mechanisms of drug resistance. To reach drug development optimization and contribute to cancer biology research, novel target drugs need to be screened. In this project, drug candidates with anticancer potential were screened for their anticancer activity and ability to inhibit DNA replication. A candidate nicknamed A-C5 was found to be a potential candidate for further investigation.

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