School of Science Division of Life Science 16 Deciphering Epigenetic Changes in Cancer -**UROP-EPIC program** Supervisor: LEUNG Danny Chi Yeu / LIFS Student: KANG Juwon / BIOT Course: UROP1100, Spring The purpose of the UROP 1100 was to equip myself with techniques widely used in the field of molecular biology to proceed with coming up a feasible research question that could be explored for the FYP. The following content of the report introduces a detailed timeline and the learnings that I had over the UROP period. Receptor Based Drug Development from Chinese Herbal Medicine Supervisor: LI Ning / LIFS Co-supervisor: XUE Hong / LIFS Student: HO Wing Chi / BIBU Course: UROP1100, Spring Interactions of drugs with specific molecular targets allow them to alter the activities of these targets. Receptors have always been a major category of target and enabled the discovery of many drugs. Meanwhile, there is a revival of drug development from plants, due to issues such as severe side effects. Practised for thousands of years, Chinese herbal medicine presents a huge source of effective medicinal herbs and therefore plays an important role in this recent trend of drug development. This review will briefly present some recent progress in receptor-based drug development from Chinese herbal medicine in the novel COVID-19 and diabetes. Although there are hurdles to be overcome, Chinese herbal medicine still possesses enormous potential in receptor-based drug development. Receptor Based Drug Development from Chinese Herbal Medicine Supervisor: LI Ning / LIFS Co-supervisor: XUE Hong / LIFS Student: KOT Yung Kei / BIBU Course: UROP1100, Summer Anxiety is one of the most common mental issues around the world. It is much related to the benzodiazepine (BZD) binding site of the gamma-aminobutyric acid type A (GABAA) receptor. Therefore, it is indispensable to understand the principle behind and find possible method to minimize the impacts from it. In this review paper, the types of ligand-gated ions channels (LGICs), structure, functions and detailed inhibitory process of GABAA receptor and the introduction of BZD are to be discussed. Wogonin and baicalin are the flavones isolated from Scutellaria baicalensis Georgi (S. baicalensis) which show significant anxiolytic effect. They have valuable potential to be applied in the therapy in the upcoming future.